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Prolonged illness can lead to a serious electrolyte imbalance, making it dangerous for you to use amlodipine and perindopril.
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But recent Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA) trial concluded that, in similar hypertensive populations without previous or current coronary artery disease, higher baseline heart rate is not an indication for preferential use of β-blocker-based therapy over amlodipine based therapy.
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Zidek W, Spiecker C, Knaup G, Steindl L, Breuer HWM "Comparison of the efficacy and safety of nifedipine coat-core versus amlodipine in the treatment of patients with mild-to-moderate essential hypertension.
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