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Their action is similar to that of the bisphosphonates.

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Addition of supplemental calcium to alendronate treatment had no effect on BMD and resulted in a small, though statistically significant, additional reduction in NTx.

Alendronate is one of several medicines known as bisphosphonates that are mainly used to reduce bone loss in older adults.

The relationship between oral bisphosphonates and GI symptoms has been examined in multiple studies, which have consistently shown that the incidence of nausea, dyspepsia, abdominal pain, and gastritis is not significantly different between alendronate, risedronate, or ibandronate and placebo.

The fracture reduction and concomitant increases in bone density generally seen with bisphosphonate use are believed to result from a decline in the activation frequency of new remodeling units formed by osteoclasts, with relative preservation (at least initially) of osteoblast activity.

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Methods: Published literature on this topic was identified by using MEDLINE (1966 to December 2006), the ACP Journal Club database, the Cochrane Central Register of Controlled Trials (no date limits), the Cochrane Database of Systematic Reviews (no date limits), Web sites of the United Kingdom National Institute of Health and Clinical Excellence (no date limits), and the United Kingdom Health Technology Assessment Program (January 1998 to December 2006).

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Calcarea phosphorica is an excellent natural medicine employed in Homeopathic treatment of curvature of spine in patients of osteoporosis.

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Endometriosis and adenomyosis are also alleviated with the onset of menopause, and many patients with pelvic pain finally achieve permanent pain relief.

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Several studies have demonstrated that OPG is a potent inhibitor of bone loss, thus regulating bone density and mass in mouse and humans.

Calcitonin (Miacalcin), taken intranasally to prevent osteoporosis, has been found anecdotally by clinicians to reduce the severity of pain from compression fractures.

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Supporting observations include the variable penetrance of Paget disease within families with a genetic predisposition; the fact that the disease remains highly localized to a particular bone or bones rather than affecting the entire skeleton; and data that reveal a declining incidence and severity of the disease over the past 20-25 years.

The results showed that nonvertebral fracture prevention with vitamin D is dose dependent, and a higher dose reduced fractures by at least 20% for individuals aged 65 years or older.

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Millions of unsuspecting dairy product consumers are led to believe that drinking cow milk and eating other 'calcium rich' dairy foods will lead to stronger, "healthier" bones.

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Women who are relatively young with no risk factors might just be advised to take more calcium and vitamin D and get more exercise to combat their risk for fractures.

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Patients should address specific medical concerns with their physicians.

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The researchers of the study found that 82 percent of the patients with atypical fractures had taken a bisphosphonate drug.

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Glucocorticoid-induced osteoporosis: skeletal manifestations of glucocorticoid use and 2004 Japanese Society for Bone and Mineral Research-proposed guidelines for its management.

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More says “One scenario might involve a patient taking a low dose of estrogen close to menopause to protect bones and help with menopausal sumptoms, followed by Evista to reduce the risk of breat cancer and oseoporosis, and then use bisphosphonates if needed later in life when hip-fracture preventuion becomes increasingly important.

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The acceptable threshold of side effects may vary by clinician and individual; those providers with a greater comfort in dealing with common adverse effects such as hand-foot syndrome may ultimately have improved outcomes.

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The studies suggest that patients at low risk of fracture (for example, younger patients without a fracture history and with a bone mineral density approaching normal) may be good candidates for discontinuation of bisphosphonate therapy after three to five years.

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